Chinureninasi
Chinureninasi è un enzima appartenente alla classe delle idrolasi, che catalizza la seguente reazione:
| Chinureninasi | |
|---|---|
 Modello tridimensionale di Chinureninasi umana (PDB 2HZP)[1] | |
| Numero EC | 3.7.1.3 |
| Classe | Idrolasi |
| Banche dati | BRENDA, EXPASY, GTD, PDB (RCSB PDB PDBe PDBj PDBsum) |
| Fonte: IUBMB | |
- L-chinurenina + H2O ⇄ antranilato + L-alanina
Note modifica
- ^ (EN) Lima S, Khristoforov R, Momany C, Phillips RS, Crystal structure of Homo sapiens kynureninase, in Biochemistry, vol. 46, n. 10, marzo 2007, pp. 2735–44, DOI:10.1021/bi0616697, PMC 2531291, PMID 17300176.
Bibliografia modifica
- Heyes MP, Chen CY, Major EO, Saito K, Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types., in Biochem. J., vol. 326, n. 2, 1997, pp. 351–6, PMC 1218677, PMID 9291104.
- Rose JE, Behm FM, Drgon T, et al., Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score., in Mol. Med., vol. 16, n. 7-8, pp. 247–53, DOI:10.2119/molmed.2009.00159, PMC 2896464, PMID 20379614.
- Zhang Y, Zhang KX, He X, et al., [A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension], in Zhonghua Xin Xue Guan Bing Za Zhi, vol. 33, n. 7, 2005, pp. 588–91, PMID 16080802.
- Inada J, Okuno E, Kimura M, Kido R, Intracellular localization and characterization of 3-hydroxykynureninase in human liver., in Int. J. Biochem., vol. 16, n. 6, 1984, pp. 623–8, PMID 6468727.
- Ubbink JB, Vermaak WJ, Bissbort SH, High-performance liquid chromatographic assay of human lymphocyte kynureninase activity levels., in J. Chromatogr., vol. 566, n. 2, 1991, pp. 369–75, PMID 1939450.
- Maruyama K, Sugano S, Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides., in Gene, vol. 138, n. 1-2, 1994, pp. 171–4, DOI:10.1016/0378-1119(94)90802-8, PMID 8125298.
- Magni G, Amici A, Emanuelli M, et al., Enzymology of NAD+ homeostasis in man., in Cell. Mol. Life Sci., vol. 61, n. 1, 2004, pp. 19–34, DOI:10.1007/s00018-003-3161-1, PMID 14704851.
- Strausberg RL, Feingold EA, Grouse LH, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2002, pp. 16899–903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
- Christensen M, Duno M, Lund AM, et al., Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase., in J. Inherit. Metab. Dis., vol. 30, n. 2, 2007, pp. 248–55, DOI:10.1007/s10545-007-0396-2, PMID 17334708.
- Walsh HA, Botting NP, Purification and biochemical characterization of some of the properties of recombinant human kynureninase., in Eur. J. Biochem., vol. 269, n. 8, 2002, pp. 2069–74, DOI:10.1046/j.1432-1033.2002.02854.x, PMID 11985583.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al., Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library., in Gene, vol. 200, n. 1-2, 1997, pp. 149–56, DOI:10.1016/S0378-1119(97)00411-3, PMID 9373149.
Altri progetti modifica
Wikimedia Commons contiene immagini o altri file su Chinureninasi
