Periostina
La periostina o osteoblast specific factor o POSTN è una proteina che nell'uomo è codificata dal gene POSTN.[2][3] La sua sovra-espressione è stata segnalata in diversi tipi di cancro; essa, infatti, si ritrova più frequente nell'ambiente circostante le cellule tumorali.[4][5]
| Periostina o osteoblast specific factor | |
|---|---|
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| Altri nomi | |
| POSTN; MGC119510; MGC119511; OSF-2; OSF2; PDLPOSTN; PN; RP11-412K4.1; periostin[1] | |
Di recente ricercatori sono riusciti nel topo a bloccare la produzione di questa proteina usando anticorpi contro essa diretti, bloccando così la formazione di metastasi.[6][7]
Note modifica
- ^ (EN) POSTN periostin, osteoblast specific factor [Homo sapiens] - Gene - NCBI, su ncbi.nlm.nih.gov.
- ^ Takeshita S, Kikuno R, Tezuka K, Amann E, Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I, in Biochem J, 294, ( Pt 1), settembre 1993, pp. 271–8, PMC 1134594, PMID 8363580.
- ^ Entrez Gene: POSTN periostin, osteoblast specific factor, su ncbi.nlm.nih.gov.
- ^ Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD, Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility, in Cancer Res, vol. 62, n. 18, settembre 2002, pp. 5358–64, PMID 12235007.
- ^ Contié S, Voorzanger-Rousselot N, Litvin J, et al., Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases., in Int. J. Cancer, vol. 128, n. 2, 2011, pp. 352–60, DOI:10.1002/ijc.25591, PMID 20715172.
- ^ Il SecoloXIX | Magazine | Salute Benessere, su ilsecoloxix.it (archiviato dall'url originale il 7 gennaio 2012).
- ^ www.vitadidonna.org [collegamento interrotto], su vitadidonna.org.
Bibliografia modifica
- Sasaki H, Dai M, Auclair D, et al., <843::AID-CNCR1391>3.0.CO;2-P Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas., in Cancer, vol. 92, n. 4, 2001, pp. 843–8, DOI:10.1002/1097-0142(20010815)92:4<843::AID-CNCR1391>3.0.CO;2-P, PMID 11550156.
- Strausberg RL, Feingold EA, Grouse LH, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al., Complete sequencing and characterization of 21,243 full-length human cDNAs., in Nat. Genet., vol. 36, n. 1, 2004, pp. 40–5, DOI:10.1038/ng1285, PMID 14702039.
- Dunham A, Matthews LH, Burton J, et al., The DNA sequence and analysis of human chromosome 13., in Nature, vol. 428, n. 6982, 2004, pp. 522–8, DOI:10.1038/nature02379, PMC 2665288, PMID 15057823.
- Shao R, Bao S, Bai X, et al., Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression., in Mol. Cell. Biol., vol. 24, n. 9, 2004, pp. 3992–4003, DOI:10.1128/MCB.24.9.3992-4003.2004, PMC 387763, PMID 15082792.
- Bao S, Ouyang G, Bai X, et al., Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway., in Cancer Cell, vol. 5, n. 4, 2004, pp. 329–39, DOI:10.1016/S1535-6108(04)00081-9, PMID 15093540.
- Kim CJ, Yoshioka N, Tambe Y, et al., Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells., in Int. J. Cancer, vol. 117, n. 1, 2005, pp. 51–8, DOI:10.1002/ijc.21120, PMID 15880581.
- Chang Y, Lee TC, Li JC, et al., Differential expression of osteoblast-specific factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal carcinoma., in Head Neck, vol. 27, n. 10, 2005, pp. 873–82, DOI:10.1002/hed.20253, PMID 16136586.
- Liu T, Qian WJ, Gritsenko MA, et al., Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry., in J. Proteome Res., vol. 4, n. 6, 2006, pp. 2070–80, DOI:10.1021/pr0502065, PMC 1850943, PMID 16335952.
- Yan W, Shao R, Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation., in J. Biol. Chem., vol. 281, n. 28, 2006, pp. 19700–8, DOI:10.1074/jbc.M601856200, PMID 16702213.
- Försti A, Jin Q, Altieri A, et al., Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis., in Breast Cancer Res. Treat., vol. 101, n. 1, 2007, pp. 83–93, DOI:10.1007/s10549-006-9265-1, PMID 16807673.
- Grigoriadis A, Mackay A, Reis-Filho JS, et al., Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data., in Breast Cancer Res., vol. 8, n. 5, 2007, pp. R56, DOI:10.1186/bcr1604, PMC 1779497, PMID 17014703.
- Baril P, Gangeswaran R, Mahon PC, et al., Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway., in Oncogene, vol. 26, n. 14, 2007, pp. 2082–94, DOI:10.1038/sj.onc.1210009, PMID 17043657.
- Siriwardena BS, Kudo Y, Ogawa I, et al., Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer., in Br. J. Cancer, vol. 95, n. 10, 2007, pp. 1396–403, DOI:10.1038/sj.bjc.6603431, PMC 2360586, PMID 17060937.
- Li JS, Sun GW, Wei XY, Tang WH, Expression of periostin and its clinicopathological relevance in gastric cancer., in World J. Gastroenterol., vol. 13, n. 39, 2007, pp. 5261–6, PMID 17876898.
- Contié S, Voorzanger-Rousselot N, Litvin J, et al., Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice., in Calcif. Tissue Int., vol. 87, n. 4, 2010, pp. 341–50, DOI:10.1007/s00223-010-9391-y, PMID 20567965.
- Kashyap MK,” et al., Overexpression of Periostin and Lumican in Esophageal Squamous Cell Carcinoma., in Cancers., vol. 2, n. 1, 2010, pp. 133–142, DOI:10.3390/cancers2010133.
- Kudo A, Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell, in Cell. Mol. Life Sci., vol. 68, n. 19, ottobre 2011, pp. 3201–7, DOI:10.1007/s00018-011-0784-5, PMC 3173633, PMID 21833583.
- L. Morra, H. Moch, Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update., in Virchows Arch, vol. 459, n. 5, novembre 2011, pp. 465-75, DOI:10.1007/s00428-011-1151-5, PMID 21997759.
- EM. Deraz, Y. Kudo; M. Yoshida; M. Obayashi; T. Tsunematsu; H. Tani; SB. Siriwardena; MR. Kiekhaee; G. Qi; S. Iizuka; I. Ogawa, MMP-10/stromelysin-2 promotes invasion of head and neck cancer., in PLoS One, vol. 6, n. 10, 2011, pp. e25438, DOI:10.1371/journal.pone.0025438, PMID 21998657.
- A. Kudo, Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell., in Cell Mol Life Sci, vol. 68, n. 19, ottobre 2011, pp. 3201-7, DOI:10.1007/s00018-011-0784-5, PMID 21833583.
- SJ. Conway, T. Doetschman; M. Azhar, The inter-relationship of periostin, TGF beta, and BMP in heart valve development and valvular heart diseases., in ScientificWorldJournal, vol. 11, 2011, pp. 1509-24, DOI:10.1100/tsw.2011.132, PMID 21805020.
- Y. Liu, BA. Liu, Enhanced proliferation, invasion, and epithelial-mesenchymal transition of nicotine-promoted gastric cancer by periostin., in World J Gastroenterol, vol. 17, n. 21, giugno 2011, pp. 2674-80, DOI:10.3748/wjg.v17.i21.2674, PMID 21677839.
