Tirosin-chinasi B-linfoide
La tirosin-chinasi B-linfoide, nota anche come chinasi B-linfocitica è un enzima della famiglia delle chinasi, codificato nell'essere umano dal gene BLK[1][2].
| Tirosin-chinasi B-linfoide | |
|---|---|
| Gene | |
| HUGO | BLK MGC10442; MODY11 |
| Entrez | 640 |
| Locus | Chr. 8 p23.1 |
| Proteina | |
| OMIM | 191305 |
| UniProt | P51451 |
| Enzima | |
| Numero EC | 2.7.10.2 |
Interazioni modifica
La tirosin-chinasi B-linfoide è stata osservata interagire con l'enzima UBE3A[3].
Note modifica
- ^ Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE, Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk), in Oncogene, vol. 10, n. 3, marzo 1995, pp. 477–86, PMID 7845672.
- ^ Entrez Gene: BLK B lymphoid tyrosine kinase, su ncbi.nlm.nih.gov.
- ^ Oda H, Kumar S, Howley PM, Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination, in Proc. Natl. Acad. Sci. U.S.A., vol. 96, n. 17, agosto 1999, pp. 9557–62, DOI:10.1073/pnas.96.17.9557, PMC 22247, PMID 10449731.
Bibliografia modifica
- Dymecki SM, Niederhuber JE, Desiderio SV, Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells., in Science, vol. 247, n. 4940, 1990, pp. 332–6, DOI:10.1126/science.2404338, PMID 2404338.
- Lin YH, Shin EJ, Campbell MJ, Niederhuber JE, Transcription of the blk gene in human B lymphocytes is controlled by two promoters., in J. Biol. Chem., vol. 270, n. 43, 1995, pp. 25968–75, DOI:10.1074/jbc.270.43.25968, PMID 7592787.
- Saouaf SJ, Kut SA, Fargnoli J, et al., Reconstitution of the B cell antigen receptor signaling components in COS cells., in J. Biol. Chem., vol. 270, n. 45, 1995, pp. 27072–8, DOI:10.1074/jbc.270.45.27072, PMID 7592958.
- Islam KB, Rabbani H, Larsson C, et al., Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk., in J. Immunol., vol. 154, n. 3, 1995, pp. 1265–72, PMID 7822795.
- Donovan JA, Wange RL, Langdon WY, Samelson LE, The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor., in J. Biol. Chem., vol. 269, n. 37, 1994, pp. 22921–4, PMID 8083187.
- Pleiman CM, Clark MR, Gauen LK, et al., Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase., in Mol. Cell. Biol., vol. 13, n. 9, 1993, pp. 5877–87, PMC 360336, PMID 8395016.
- Malek SN, Yang CH, Earnshaw WC, et al., p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains., in J. Biol. Chem., vol. 271, n. 12, 1996, pp. 6952–62, DOI:10.1074/jbc.271.12.6952, PMID 8636124.
- Bewarder N, Weinrich V, Budde P, et al., In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation., in Mol. Cell. Biol., vol. 16, n. 9, 1996, pp. 4735–43, PMC 231474, PMID 8756631.
- Saouaf SJ, Wolven A, Resh MD, Bolen JB, Palmitylation of Src family tyrosine kinases regulates functional interaction with a B cell substrate., in Biochem. Biophys. Res. Commun., vol. 234, n. 2, 1997, pp. 325–9, DOI:10.1006/bbrc.1997.6638, PMID 9177269.
- Hegde R, Srinivasula SM, Ahmad M, et al., Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist., in J. Biol. Chem., vol. 273, n. 14, 1998, pp. 7783–6, DOI:10.1074/jbc.273.14.7783, PMID 9525867.
- Oda H, Kumar S, Howley PM, Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination., in Proc. Natl. Acad. Sci. U.S.A., vol. 96, n. 17, 1999, pp. 9557–62, DOI:10.1073/pnas.96.17.9557, PMC 22247, PMID 10449731.
- Appel S, Filter M, Reis A, et al., Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759., in Eur. J. Hum. Genet., vol. 10, n. 1, 2002, pp. 17–25, DOI:10.1038/sj.ejhg.5200750, PMID 11896452.
- Lee S, Ha S, Chung M, et al., Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells., in Cancer Lett., vol. 188, n. 1-2, 2003, pp. 121–6, DOI:10.1016/S0304-3835(02)00055-1, PMID 12406557.
- Strausberg RL, Feingold EA, Grouse LH, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
- Cho JY, Akbarali Y, Zerbini LF, et al., Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene., in J. Biol. Chem., vol. 279, n. 19, 2004, pp. 19512–22, DOI:10.1074/jbc.M309074200, PMID 14970218.
Collegamenti esterni modifica
- Mesh, su nlm.nih.gov.
