Ducati is best known for high performance motorcycles characterized by large capacity four-stroke, L-twin (90° twin-cylinder)[11] engines featuring a desmodromic valve design.[12] Modern Ducatis remain among the dominant performance motorcycles available today partly because of the desmodromic valve design, which is nearing its 50th year of use. Desmodromic valves are closed with a separate, dedicated cam lobe and lifter instead of the conventional valve springs used in most internal combustion engines in consumer vehicles. This allows the cams to have a more radical profile, thus opening and closing the valves more quickly without the risk of valve-float, which causes a loss of power, that is likely when using a "passive" closing mechanism under the same conditions.

While most other manufacturers utilize wet clutches (with the spinning parts bathed in oil)[13] Ducati uses multiplate dry clutches in many of their current motorcycles. The dry clutch eliminates the power loss from oil viscosity drag on the engine even though the engagement may not be as smooth as the oil bath versions, and the clutch plates can wear more rapidly.