Utente:Grasso Luigi/sanbox1/Esterificazione: differenze tra le versioni

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Grasso Luigi (discussione | contributi)
Grasso Luigi (discussione | contributi)
Riga 15:
* Rimuovere acqua con un mezzo fisico come la [[distillazione]], un [[azeotropo]] basso bollente con [[toluene]], in combinazione con un [[apparato di Dean-Stark]].
 
Reagents are known that drive the dehydration of mixtures of alcohols and carboxylic acids. One example is the [[Steglich esterification]], which is a method of forming esters under mild conditions. The method is popular in [[peptide synthesis]], where the substrates are sensitive to harsh conditions like high heat. DCC ([[dicyclohexylcarbodiimide]]) is used to activate the carboxylic acid to further reaction. [[4-Dimethylaminopyridine]] (DMAP) is used as an acyl-transfer [[catalyst]].<ref>{{OrgSynth |autore= B. Neises; W. Steglich. |anno= |titolo=Esterification of Carboxylic Acids with Dicyclohexylcarbodiimide/4-Dimethylaminopyridine: ''tert''-Butyl ethyl fumarate |volume= |pp=|doi= |collanno= |collvolume=7 |collvolpp= 93 |prep=cv7p0093}}<ref/ref>
 
:[[File:Steglich-1.svg|300px]]