BMS-945429: differenze tra le versioni

L''''ALD518''' ora '''BMS-945.429''' è un anticorpo monoclonale umanizzato a[[Glicoside|glicosilato]], attivo contro l'[[interleuchina]]-6 . Si tratta di un farmaco sperimentale per il cancro e l'[[artrite reumatoide]] ciò grazie grazie alle sue proprietà anti-infiammatorie.<ref name="urlPhase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer — Clin Cancer Res">{{citeCita web | url = http://clincancerres.aacrjournals.org/content/12/18/5503.abstract | titletitolo = Phase I Study of Abagovomab in Patients with Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer — Clin Cancer Res | authorautore = | authorlinkwkautore = | coauthorscoautori = | datedata = | formatformato = | workopera = | publishereditore = | pagespagine = | languagelingua = en | archiveurlurlarchivio = | archivedatedataarchivio = | quote = | accessdateaccesso = }}</ref>

L'[[emivita]] relativamente lunga di circa 30 giorni dovrebbe consentire la riduzione delle frequenti iniezioni sottocutanee.<ref name="urlAlder Sets Stage for Showdown With Roche, With “Fast Follower” Antibody Drug Strategy | Xconomy">{{citeCita web | url = http://www.xconomy.com/seattle/2008/09/18/alder-sets-stage-for-showdown-with-roche-with-fast-follower-antibody-drug-strategy/ | titletitolo = Alder Sets Stage for Showdown With Roche, With “Fast Follower” Antibody Drug Strategy &#124; Xconomy | authorautore = | authorlinkwkautore = | coauthorscoautori = | datedata = | formatformato = | workopera = | publishereditore = | pagespagine = | languagelingua = en | archiveurlurlarchivio = | archivedatedataarchivio = | quote = | accessdateaccesso = }}</ref>

Viene realizzato con cellule di [[lievito]] piuttosto che secondo lo standard con delle cellule ovariche di [[criceto]] cinese.<ref name="urlAlder Sets Stage for Showdown With Roche, With “Fast Follower” Antibody Drug Strategy | Xconomy">{{citeCita web | url = http://www.xconomy.com/seattle/2008/09/18/alder-sets-stage-for-showdown-with-roche-with-fast-follower-antibody-drug-strategy/ | titletitolo = Alder Sets Stage for Showdown With Roche, With “Fast Follower” Antibody Drug Strategy &#124; Xconomy | authorautore = | authorlinkwkautore = | coauthorscoautori = | datedata = | formatformato = | workopera = | publishereditore = | pagespagine = | languagelingua = en | archiveurlurlarchivio = | archivedatedataarchivio = | quote = | accessdateaccesso = }}</ref>

* {{citeCita booklibro|authorautore=Frank Ashall|titletitolo=Le grandi scoperte scientifiche|url=http://books.google.com/books?id=GXsecqAh6MEC&pg=PA245|accessdatedatadiaccesso=|yearanno=1999|publishereditore=Armando Editore|isbnid=ISBN 9788871449494|pagespagine=245–}}

* {{citeCita booklibro|author1=Abul K. Abbas|author2=Andrew H. Lichtman|author3=Shiv Pillai|titletitolo=Immunologia cellulare e molecolare|url=http://books.google.com/books?id=9SFm3nMO_gUC&pg=PA79|accessdatedatadiaccesso= |yearanno=2010|publishereditore=Elsevier srl|isbnid=ISBN 9788821431760|pagespagine=79–}}

* {{citeCita booklibro|author1=Abul K. Abbas|author2=Andrew H. Lichtman|titletitolo=Le basi dell'immunologia|url=http://books.google.com/books?id=szHkdI9buskC&pg=PA70|accessdate|yearanno=2006|publishereditore=Elsevier srl|isbnid=ISBN 9788885675858|pagespagine=70–}}

* {{citeCita booklibro|author1=Humphrey P. Rang|author2=M. Maureen Dale|author3=James M. Ritter|titletitolo=Farmacologia|url=http://books.google.com/books?id=HGcP_ip4SmgC&pg=PA778|accessdate|yearanno=2008|publishereditore=Elsevier srl|isbnid=ISBN 9788821430237|pagespagine=778–}}

* {{citeCita booklibro|authorautore=Enzo Fagiolo|titletitolo=Immunoematologia|url=http://books.google.com/books?id=ErRtMU7SKhkC&pg=PA16|accessdatedatadiaccesso=|yearanno=2007|publishereditore=Mediserve s.r.l.|isbnid=ISBN 9788882041359|pagespagine=16–}}

* {{citeCita booklibro|authorautore=Paolo Larizza|titletitolo=Trattato di medicina interna|url=http://books.google.com/books?id=Rt4_C55_Ls4C&pg=PA909|accessdatedatadiaccesso=|yearanno=2005|publishereditore=PICCIN|isbnid=ISBN 9788829917211|pagespagine=909–}}

* {{citeCita booklibro|authorautore=Angelo Sghirlanzoni|titletitolo=Terapia Delle Malattie Neurologiche|url=http://books.google.com/books?id=LCNUGXlL4FQC&pg=PA113|accessdatedatadiaccesso= |datedata=3 Aprilaprile 2010|publishereditore=Springer|isbnid=ISBN 9788847011199|pagespagine=113–}}

* {{citeCita booklibro|authorautore=Thomas C. King|titletitolo=Patologia|url=http://books.google.com/books?id=1CgV-Td_I3oC&pg=PA156|accessdatedatadiaccesso= |yearanno=2008|publishereditore=Elsevier srl|isbnid=ISBN 9788821430190|pagespagine=156–}}

* {{citeCita web | url = http://whqlibdoc.who.int/druginfo/INN_2000_list43.pdf WHO-Lista INN degli Anticorpi monoclonali| titletitolo = whqlibdoc.who.int | authorautore = | authorlinkwkautore = | coauthorscoautori = | datedata =|formatformato = | workopera = | publishereditore = | pagespagine = | languagelingua = en | archiveurlurlarchivio = | archivedatedataarchivio = | quote =| accessdateaccesso = }}

* {{en}}{{citeCita booklibro|authorautore=Marie A. Simmons|titletitolo=Monoclonal antibodies: new research|url=http://books.google.com/books?id=jxhKskARw6IC|accessdatedatadiaccesso=|yearanno=2005|publishereditore=Nova Publishers|isbnid=ISBN 9781594542473}}

* {{en}}{{citeCita booklibro|authorautore=Zhiqiang An|titletitolo=Therapeutic Monoclonal Antibodies: From Bench to Clinic|url=http://books.google.com/books?id=agdx2rtK7E0C|accessdatedatadiaccesso= |datedata=8 Septembersettembre 2009|publishereditore=John Wiley and Sons|isbnid=ISBN 9780470117910}}

* {{en}}{{citeCita booklibro|authorautore=James W. Goding|titletitolo=Monoclonal antibodies: principles and practice : production and application of monoclonal antibodies in cell biology, biochemistry and immunology|url=http://books.google.com/books?id=jPk4ZY4CnQQC|accessdatedatadiaccesso=|yearanno=1996|publishereditore=Academic Press|isbnid=ISBN 9780122870231}}

* {{en}}{{citeCita booklibro|authorautore=Steve Shire|titletitolo=Current Trends in Monoclonal Antibody Development and Manufacturing|url=http://books.google.com/books?id=YTbJpdPhgT4C|accessdatedatadiaccesso= |datedata=April 2009|publishereditore=Springer|isbnid=ISBN 9780387766423}}