tRNA (guanina-N2-)-metiltransferasi
enzima
(Reindirizzamento da TRNA guanina 2-metiltransferasi)
La tRNA (guanina-N2-)-metiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione:
| tRNA (guanina-N2-)-metiltransferasi | |
|---|---|
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| Numero EC | 2.1.1.214 |
| Classe | Transferasi |
| Nome sistematico | |
| S-adenosil-L-metionina:tRNA (guanina-N2-)-metiltransferasi | |
| Altri nomi | |
| transfer ribonucleato guanina 2-metiltransferasi; tRNA guanina 2-metiltransferasi; S-adenosil-L-metionina:tRNA (guanina-2-N-)-metiltransferasi | |
| Banche dati | BRENDA, EXPASY, GTD, PDB (RCSB PDB PDBe PDBj PDBsum) |
| Fonte: IUBMB | |
- S-adenosil-L-metionina + tRNA ⇄ S-adenosil-L-omocisteina + tRNA contenente N2-metilguanina
Nei tRNA eucariotici sono portate a termine due metilazioni della N2-guanina, in posizione 10 e 29.
Bibliografia modifica
- Krauss, J. and Stahelin, M., N2-Guanine specific transfer RNA methyltransferase II from rat liver, in Nucleic Acids Res., vol. 1, 1974, pp. 1479–1496.
- Krauss, J. and Stahelin, M., N2-Guanine specific transfer RNA methyltransferase I from rat liver and leukemic rat spleen, in Nucleic Acids Res., vol. 1, 1974, pp. 1455–1478.
- Izzo, P. and Gantt, R., Partial purification and characterization of an N2-guanine RNA methyltransferase from chicken embryos, in Biochemistry, vol. 16, 1977, pp. 3576–3581, Entrez PubMed 19056.
- Glick, J.M., Ross, S. and Leboy, P.S., S-Adenosylhomocysteine inhibition of three purified tRNA methyltransferases from rat liver, in Nucleic Acids Res., vol. 2, 1975, pp. 1639–1651, Entrez PubMed 1208211.
- Glick, J.M., Averyhart, V.M. and Leboy, P.S., Purification and characterization of two tRNA-(guanine)-methyltransferases from rat liver, in Biochim. Biophys. Acta, vol. 518, 1978, pp. 158–171, Entrez PubMed 629973.
- Björk, G.R. and Svensson, I., Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae, in Eur. J. Biochem., vol. 9, 1969, pp. 207–215, Entrez PubMed 69267419.
- Baguley, B.C. and Staehelin, M., The specificity of transfer ribonucleic acid methylases from rat liver, in Biochemistry, vol. 7, 1968, pp. 45–50, Entrez PubMed 4921283.
- Agris, P.F., Spremulli, L. and Brown, G.M., tRNA methylases from HeLa cells: purification and properties of an adenine-1-methylase and a guanine-N2-methylase, in Arch. Biochem. Biophys., vol. 162, 1974, pp. 38–47, Entrez PubMed 4208689.
